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非正则模型的最优试验设计AI 解读

Classically, Fisher information is the relevant object in defining optimal experimental designs. However, for models that lack certain regularity, the Fisher information does not exist, and hence, there is no notion of design optimality available in the literature. This article seeks to fill the gap by proposing a so-called Hellinger information, which generalizes Fisher information in the sense that the two measures agree in regular problems, but the former also exists for…

大数据线性回归中基于信息的最优子数据选择AI 解读

Extraordinary amounts of data are being produced in many branches of science. Proven statistical methods are no longer applicable with extraordinary large datasets due to computational limitations. A critical step in big data analysis is data reduction. Existing investigations in the context of linear regression focus on subsampling-based methods. However, not only is this approach prone to sampling errors, it also leads to a covariance matrix of the estimators that is…

论 de la Garza 现象AI 解读

Deriving optimal designs for nonlinear models is, in general, challenging. One crucial step is to determine the number of support points needed. Current tools handle this on a case-by-case basis. Each combination of model, optimality criterion and objective requires its own proof. The celebrated de la Garza Phenomenon states that under a (p−1)th-degree polynomial regression model, any optimal design can be based on at most p design points, the minimum number of support…

双参数非线性模型局部最优设计的支撑点AI 解读

We propose a new approach for identifying the support points of a locally optimal design when the model is a nonlinear model. In contrast to the commonly used geometric approach, we use an approach based on algebraic tools. Considerations are restricted to models with two parameters, and the general results are applied to often used special cases, including logistic, probit, double exponential and double reciprocal models for binary data, a loglinear Poisson regression model…

一致性评估的统计方法AI 解读

Measurements of agreement are needed to assess the acceptability of a new or generic process, methodology, and formulation in areas of laboratory performance, instrument or assay validation, method comparisons, statistical process control, goodness of fit, and individual bioequivalence. In all of these areas, one needs measurements that capture a large proportion of data that are within a meaningful boundary from target values. Target values can be considered random…