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检测异质组织跨样本空间表达变异的灵活贝叶斯框架AI 解读

Spatial transcriptomics measures gene expression alongside the spatial coordinates of each capture spot or cell across tissue samples. The detection of spatially variable (SV) genes, whose expression exhibits systematic spatial variation, enables the delineation of functional tissue domains and the identification of region-specific transcriptional changes that underlie disease heterogeneity. However, empirical evidence from spatial transcriptomics data indicates that…

存在隐藏混杂时过参数化模型的在线推断AI 解读

Abstract In this paper, we study online estimation and inference of regression coefficients in the presence of hidden confounders by leveraging over-parameterized models. Unlike existing offline approaches that rely on factor and sparse models, our closed-form estimator simultaneously removes hidden-confounder bias and is directly applicable to streaming data. Using tools from random matrix theory, we analyse phase transition phenomena in the variance of the coefficient…

通过联合正则化深度神经网络估计单细胞异质基因网络AI 解读

Estimation of intracellular gene networks has been a critical component of single-cell transcriptomic data analysis, which can provide crucial insights into the complex interplay between genes, facilitating the discovery of the biological basis of human life at single-cell resolution. Despite notable achievements, existing methodologies often falter in their practicality, primarily due to their narrow focus on simplistic linear relationships and inadequate handling of…