A Bayesian Model for Detecting Acute Change in Nonlinear Profiles
检测非线性个体曲线急剧变化的贝叶斯模型
We propose a model for longitudinal data with random effects that includes model-based smoothing of measurements over time. This research is motivated by experiments evaluating the hemodynamic effects of various agents in tumor-bearing rats. In one set of experiments, the rats breathed room air, followed by carbogen (a mixture of pure oxygen and carbon dioxide). The experimental responses are longitudinal measurements of oxygen pressure measured in tissue, tumor blood flow,…