Clustering of Translocation Breakpoints
染色体易位断点的聚集分析
Translocation, a physical movement of genetic material from one chromosome to another, can result in the aberrant linkage of two cellular genes. This type of fusion may disrupt cellular function by producing novel, biologically active fused genes, or by triggering the activation of normally quiescent growth-associated genes. Either of these mechanisms provides a putative oncogenic stimulus, and indeed, several gene fusions from translocations have been identified in…