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贝叶斯距离聚类中的凝聚与排斥AI 解读

Clustering in high-dimensions poses many statistical challenges. While traditional distance-based clustering methods are computationally feasible, they lack probabilistic interpretation and rely on heuristics for estimation of the number of clusters. On the other hand, probabilistic model-based clustering techniques often fail to scale and devising algorithms that are able to effectively explore the posterior space is an open problem. Based on recent developments in Bayesian…

无穷远有多远？有限混合模型的贝叶斯非参数视角AI 解读

Mixture models are one of the most widely used statistical tools when dealing with data from heterogeneous populations. Following a Bayesian nonparametric perspective, we introduce a new class of priors: the Normalized Independent Point Process. We investigate the probabilistic properties of this new class and present many special cases. In particular, we provide an explicit formula for the distribution of the implied partition, as well as the posterior characterization of…

复杂生物混合物代谢物解卷积与定量的贝叶斯核磁共振谱模型AI 解读

Nuclear magnetic resonance (NMR) spectra are widely used in metabolomics to obtain profiles of metabolites dissolved in biofluids such as cell supernatants. Methods for estimating metabolite concentrations from these spectra are presently confined to manual peak fitting and to binning procedures for integrating resonance peaks. Extensive information on the patterns of spectral resonance generated by human metabolites is now available in online databases. By incorporating…

通过非齐次马尔可夫链模拟实现最优贝叶斯设计AI 解读

We consider decision problems defined by a utility function and an underlying probability model for all unknowns. The utility function quantifies the decision maker's preferences over consequences. The optimal decision maximizes the expected utility function where the expectation is taken with respect to all unknowns, that is, future data and parameters. In many problems, the solution is not analytically tractable. For example, the utility function might involve moments that…

依赖随机测度的 ANOVA 模型AI 解读

We consider dependent nonparametric models for related random probability distributions. For example, the random distributions might be indexed by a categorical covariate indicating the treatment levels in a clinical trial and might represent random effects distributions under the respective treatment combinations. We propose a model that describes dependence across random distributions in an analysis of variance (ANOVA)-type fashion. We define a probability model in such a…