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利用电子病历中的回顾性既患信息：重新审视成对伪似然AI 解读

Electronic health records offer abundant data on various diseases and health conditions, enabling researchers to explore the relationship between disease onset age and underlying risk factors.Unlike mortality data, the event of interest is nonterminal, hence, individuals can retrospectively report their disease-onset-age upon recruitment to the study.These individuals, diagnosed with the disease before entering the study, are termed "prevalent." The ascertainment imposes a…

大型电子健康记录分析：稀有事件下的最优 Cox 回归子抽样AI 解读

Massive sized survival datasets become increasingly prevalent with the development of the healthcare industry, and pose computational challenges unprecedented in traditional survival analysis use cases. In this work we analyze the UK-biobank colorectal cancer data with genetic and environmental risk factors, including a time-dependent coefficient, which transforms the dataset into “pseudo-observation” form, thus, critically inflating its size. A popular way for coping with…

基于边际化脆弱性的疾病—死亡模型：英国生物样本库应用AI 解读

The UK Biobank is a large-scale health resource comprising genetic, environmental, and medical information on approximately 500,000 volunteer participants in the United Kingdom, recruited at ages 40–69 during the years 2006–2010. The project monitors the health and well-being of its participants. This work demonstrates how these data can be used to yield the building blocks for an interpretable risk-prediction model, in a semiparametric fashion, based on known genetic and…

基于人群的病例对照研究中危险率函数的估计AI 解读

The population-based case-control study design has been widely used for studying the etiology of chronic diseases. It is well established that the Cox proportional hazards model can be adapted to the case-control study and hazard ratios can be estimated by (conditional) logistic regression model with time as either a matched set or a covariate (Prentice and Breslow, 1978). However, the baseline hazard function, a critical component in absolute risk assessment, is…

事件发生时间测量误差的非参数校正：风险预测模型应用AI 解读

Mismeasured time to event data used as a predictor in risk prediction models will lead to inaccurate predictions. This arises in the context of self-reported family history, a time to event predictor often measured with error, used in Mendelian risk prediction models. Using validation data, we propose a method to adjust for this type of error. We estimate the measurement error process using a nonparametric smoothed Kaplan-Meier estimator, and use Monte Carlo integration to…

一般半参数共享脆弱性模型下的病例对照生存分析：伪完整似然方法AI 解读

In this work we deal with correlated failure time (age at onset) data arising from population-based, case-control studies, where case and control probands are selected by population-based sampling and an array of risk factor measures is collected for both cases and controls and their relatives. Parameters of interest are effects of risk factors on the failure time hazard function and within-family dependencies among failure times after adjusting for the risk factors. Due to…

一般半参数共享脆弱性模型的前瞻生存分析：伪完全似然方法AI 解读

We provide a simple estimation procedure for a general frailty model for the analysis of prospective correlated failure times. The large-sample properties of the proposed estimators of both the regression coefficient vector and the dependence parameter are described, and consistent variance estimators are given. A brief outline of the proofs is given. In a simulation study under the widely used gamma frailty model, our proposed approach was found to have essentially the same…

协变量测量误差下配对失效时间依赖性的估计AI 解读

Summary In many biomedical studies, covariates are subject to measurement error. Although it is well known that the regression coefficients estimators can be substantially biased if the measurement error is not accommodated, there has been little study of the effect of covariate measurement error on the estimation of the dependence between bivariate failure times. We show that the dependence parameter estimator in the Clayton–Oakes model can be considerably biased if the…