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利用半竞争风险模型估计治疗转换下的治疗效应：结直肠癌研究应用AI 解读

Treatment switching is a frequent occurrence in clinical trials, where, during the course of the trial, patients who fail on the control treatment may change to the experimental treatment. Analysing the data without accounting for switching yields highly biased and inefficient estimates of the treatment effect. In this paper, we propose a novel class of semiparametric semicompeting risks transition survival models to accommodate treatment switches. Theoretical properties of…

二元响应数据的灵活广义 t 链接模型AI 解读

A critical issue in modelling binary response data is the choice of the links. We introduce a new link based on the generalized t-distribution. There are two parameters in the generalized t-link: one parameter purely controls the heaviness of the tails of the link and the second parameter controls the scale of the link. Two major advantages are offered by the generalized t-links. First, a symmetric generalized t-link with an unknown shape parameter is much more identifiable…

分类数据的贝叶斯准则式模型评估AI 解读

We propose a general Bayesian criterion for model assessment for categorical data called the weighted L measure, which is constructed from the posterior predictive distribution of the data. The measure is based on weighting the observations according to the sampling variance of their future response vector. The weight component in the weighted L measure plays the role of a penalty term in the criterion, in which a greater weight assigned to covariate values implies a greater…