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病例定义与设计敏感度AI 解读

In a case-referent study, cases of disease are compared to non-cases with respect to their antecedent exposure to a treatment in an effort to determine whether exposure causes some cases of the disease. Because exposure is not randomly assigned in the population, as it would be if the population were a vast randomized trial, exposed and unexposed subjects may differ prior to exposure with respect to covariates that may or may not have been measured. After controlling for…

竞争传染病原体的贝叶斯建模：实验室结果不完整的流感研究AI 解读

In seasonal influenza epidemics, pathogens such as respiratory syncytial virus (RSV) often co-circulate with influenza and cause influenza-like illness (ILI) in human hosts. However, it is often impractical to test for each potential pathogen or to collect specimens for each observed ILI episode, making inference about influenza transmission difficult. In the setting of infectious diseases, missing outcomes impose a particular challenge because of the dependence among…

存在个体间干扰时的因果推断AI 解读

A fundamental assumption usually made in causal inference is that of no interference between individuals (or units); that is, the potential outcomes of one individual are assumed to be unaffected by the treatment assignment of other individuals. However, in many settings, this assumption obviously does not hold. For example, in the dependent happenings of infectious diseases, whether one person becomes infected depends on who else in the population is vaccinated. In this…

疫苗对感染后二元结局的因果效应AI 解读

The effects of vaccine on postinfection outcomes, such as disease, death, and secondary transmission to others, are important scientific and public health aspects of prophylactic vaccination. As a result, evaluation of many vaccine effects condition on being infected. Conditioning on an event that occurs posttreatment (in our case, infection subsequent to assignment to vaccine or control) can result in selection bias. Moreover, because the set of individuals who would become…

利用二代罹患率估计疫苗效力AI 解读

Epidemiologists have used secondary attack rates (SARs) to estimate the protective effects of vaccination since the 1930s. SARs can also be used to estimate the effect of vaccination on reducing infectiousness in breakthrough cases. The conventional SAR approach has been to pool the denominators and numerators across transmission units, then to use a confidence interval for a simple relative risk. We demonstrate appropriate model-based methods to estimate vaccine efficacy…