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贝叶斯层级曲线配准AI 解读

Functional data often exhibit a common shape, but with variations in amplitude and phase across curves. The analysis often proceeds by synchronization of the data through curve registration. In this article we propose a Bayesian hierarchical model for curve registration. Our hierarchical model provides a formal account of amplitude and phase variability while borrowing strength from the data across curves in the estimation of the model parameters. We discuss extensions of…

利用纵向标志物建模疾病进展AI 解读

In this paper we propose a Bayesian natural history model for disease progression based on the joint modeling of longitudinal biomarker levels, age at clinical detection of disease and disease status at diagnosis. We establish a link between the longitudinal responses and the natural history of the disease by using an underlying latent disease process which describes the onset of the disease and models the transition to an advanced stage of the disease as dependent on the…