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Predictions as Surrogates: Revisiting Surrogate Outcomes in the Age of AI

将预测作为替代结果:人工智能时代重新审视替代结局

Abstract We establish a formal connection between the decades-old surrogate outcome model in biostatistics and economics and the emerging field of prediction-powered inference. The connection treats predictions from pre-trained models, prevalent in the age of AI, as cost-effective surrogates for expensive outcomes that are not fully observed. Building on the surrogate outcomes literature, we develop recalibrated prediction-powered inference, a more efficient approach to…

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Estimating the false discovery rate of variable selection

变量选择的假发现率估计

We introduce a generic estimator for the false discovery rate of any model selection procedure, in common statistical modeling settings including the Gaussian linear model, Gaussian graphical model, and model-X setting. We prove that our method has a conservative (nonnegative) bias in finite samples under standard statistical assumptions, and provide a bootstrap method for assessing its standard error. For methods like the Lasso, forward-stepwise regression, and the…

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Discussion of “Data Fission: Splitting a Single Data Point” – Some Asymptotic Results for Data Fission

《数据裂分:拆分单个数据点》讨论:数据裂分的若干渐近结果

This comment was presented as part of the JSM 2024 JASA Theory and Methods invited session Data Fission: Splitting a Single Data Point.1 Leiner et al. (2025) introduce the data fission technique, w...

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Adaptive novelty detection with false discovery rate guarantee

具有错误发现率保证的自适应新异检测

This paper studies the semisupervised novelty detection problem where a set of “typical” measurements is available to the researcher. Motivated by recent advances in multiple testing and conformal inference, we propose AdaDetect, a flexible method that is able to wrap around any probabilistic classification algorithm and control the false discovery rate (FDR) on detected novelties in finite samples without any distributional assumption other than exchangeability. In contrast…

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Design‐robust two‐way‐fixed‐effects regression for panel data

面板数据中对分配设计稳健的双向固定效应回归

We propose a new estimator for average causal effects of a binary treatment with panel data in settings with general treatment patterns. Our approach augments the popular two‐way‐fixed‐effects specification with unit‐specific weights that arise from a model for the assignment mechanism. We show how to construct these weights in various settings, including the staggered adoption setting, where units opt into the treatment sequentially but permanently. The resulting estimator…

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Conformalized survival analysis

保形化生存分析

Abstract In this paper, we develop an inferential method based on conformal prediction, which can wrap around any survival prediction algorithm to produce calibrated, covariate-dependent lower predictive bounds on survival times. In the Type I right-censoring setting, when the censoring times are completely exogenous, the lower predictive bounds have guaranteed coverage in finite samples without any assumptions other than that of operating on independent and identically…

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Testing for outliers with conformal p-values

利用共形 p 值检验异常值

This paper studies the construction of p-values for nonparametric outlier detection, from a multiple-testing perspective. The goal is to test whether new independent samples belong to the same distribution as a reference data set or are outliers. We propose a solution based on conformal inference, a general framework yielding p-values that are marginally valid but mutually dependent for different test points. We prove these p-values are positively dependent and enable exact…

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Conditional calibration for false discovery rate control under dependence

依赖情形下控制错误发现率的条件校准

We introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the dependence is known. Our approach separately calibrates a data-dependent p-value rejection threshold for each hypothesis, relaxing or tightening the threshold as appropriate to target exact FDR control. In addition to our general framework, we propose a concrete algorithm, the dependence-adjusted Benjamini–Hochberg…

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Regression adjustment in completely randomized experiments with a diverging number of covariates

协变量数量增长时完全随机实验中的回归调整

Summary Randomized experiments have become important tools in empirical research. In a completely randomized treatment-control experiment, the simple difference in means of the outcome is un- biased for the average treatment effect, and covariate adjustment can further improve the efficiency without assuming a correctly specified outcome model. In modern applications, experimenters often have access to many covariates, motivating the need for a theory of covariate adjustment…

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Conformal Inference of Counterfactuals and Individual Treatment Effects

反事实与个体处理效应的共形推断

Abstract Evaluating treatment effect heterogeneity widely informs treatment decision making. At the moment, much emphasis is placed on the estimation of the conditional average treatment effect via flexible machine learning algorithms. While these methods enjoy some theoretical appeal in terms of consistency and convergence rates, they generally perform poorly in terms of uncertainty quantification. This is troubling since assessing risk is crucial for reliable…

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An assumption-free exact test for fixed-design linear models with exchangeable errors

可交换误差下固定设计线性模型的精确检验

Summary We propose the cyclic permutation test to test general linear hypotheses for linear models. The test is nonrandomized and valid in finite samples with exact Type I error $\alpha$ for an arbitrary fixed design matrix and arbitrary exchangeable errors, whenever $1 / \alpha$ is an integer and $n / p \geqslant 1 / \alpha - 1$, where $n$ is the sample size and $p$ is the number of parameters. The test involves applying the marginal rank test to $1 / \alpha$ linear…

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A general interactive framework for false discovery rate control under structural constraints

结构约束下控制错误发现率的一般交互框架

Summary We propose a general framework based on selectively traversed accumulation rules for interactive multiple testing with generic structural constraints on the rejection set. It combines accumulation tests from ordered multiple testing with data-carving ideas from post-selection inference, allowing highly flexible adaptation to generic structural information. Our procedure defines an interactive protocol for gradually pruning a candidate rejection set, beginning with…

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Overlap in observational studies with high-dimensional covariates

高维协变量观察性研究中的重叠性

Estimating causal effects under exogeneity hinges on two key assumptions: unconfoundedness and overlap. Researchers often argue that unconfoundedness is more plausible when more covariates are included in the analysis. Less discussed is the fact that covariate overlap is more difficult to satisfy in this setting. In this paper, we explore the implications of overlap in observational studies with high-dimensional covariates and formalize curse-of-dimensionality argument,…

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AdaPT: An Interactive Procedure for Multiple Testing with Side Information

AdaPT:利用辅助信息的交互式多重检验程序

Summary We consider the problem of multiple-hypothesis testing with generic side information: for each hypothesis Hi we observe both a p-value pi and some predictor xi encoding contextual information about the hypothesis. For large-scale problems, adaptively focusing power on the more promising hypotheses (those more likely to yield discoveries) can lead to much more powerful multiple-testing procedures. We propose a general iterative framework for this problem, the adaptive…

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