Conditional Second-Order Generalized Estimating Equations for Generalized Linear and Nonlinear Mixed-Effects Models
广义线性与非线性混合效应模型的条件二阶广义估计方程
Generalized linear and nonlinear mixed-effects models are used extensively in health care research, including applications in pharmacokinetics, clinical trials, and epidemiology. Because the underlying model may be nonlinear in the random effects, there will generally be no closed-form expression for the marginal likelihood or indeed for the marginal moments. Consequently, estimation is often carried out either using numerical integration techniques or by approximating the…