Analyzing Single-Molecule Protein Transportation Experiments via Hierarchical Hidden Markov Models
通过分层隐马尔可夫模型分析单分子蛋白质运输实验
To maintain proper cellular functions, over 50% of proteins encoded in the genome need to be transported to cellular membranes. The molecular mechanism behind such a process, often referred to as protein targeting, is not well understood. Single-molecule experiments are designed to unveil the detailed mechanisms and reveal the functions of different molecular machineries involved in the process. The experimental data consist of hundreds of stochastic time traces from the…