Permutation $p$-value approximation via generalized Stolarsky invariance
通过广义 Stolarsky 不变性近似置换检验 p 值
It is common for genomic data analysis to use $p$-values from a large number of permutation tests. The multiplicity of tests may require very tiny $p$-values in order to reject any null hypotheses and the common practice of using randomly sampled permutations then becomes very expensive. We propose an inexpensive approximation to $p$-values for two sample linear test statistics, derived from Stolarsky’s invariance principle. The method creates a geometrically derived…