Bayesian Emulation and Calibration of a Stochastic Computer Model of Mitochondrial DNA Deletions in Substantia Nigra Neurons
黑质神经元线粒体DNA缺失随机计算模型的贝叶斯仿真代理与校准
This article considers the problem of parameter estimation for a stochastic biological model of mitochondrial DNA population dynamics using experimental data on deletion mutation accumulation. The stochastic model is an attempt to describe the hypothesized link between deletion accumulation and neuronal loss in the substantia nigra region of the human brain. Inference for the parameters of the model is complicated by the fact that the model is both analytically intractable…