On Adaptive Extensions of Group Sequential Trials for Clinical Investigations
临床研究中组序贯试验的自适应延长
In group sequential trials, it is important to obtain adequate data to assess overall benefits and risks of an experimental treatment for patients. To achieve this goal, we provide a general, formal framework for adaptively extending a group sequential trial to stop at any interim analysis time, often after a significance boundary for a clinical endpoint is crossed. For statistical inference, we propose to order the sample space by a class of well-ordered group sequential…