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多计数表特征交互的稀疏贝叶斯组因子模型AI 解读

Group factor models have been developed to infer relationships between multiple co-occurring multivariate continuous responses. Motivated by complex count data from multi-domain microbiome studies using next-generation sequencing, we develop a sparse Bayesian group factor model (Sp-BGFM) for multiple count table data that captures the interaction between microorganisms in different domains. Sp-BGFM uses a rounded kernel mixture model using a Dirichlet process (DP) prior with…

基于疗效与毒性联合效用的两周期贝叶斯剂量探索AI 解读

Juhee Lee, Peter F. Thall, Yuan Ji & Peter MüllerJuhee Lee, Department of Statistics, Ohio State University, Columbus, OH 43210 (E-mail: ).Peter F. Thall, Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77230-1402 (E-mail: ).Yuan Ji, Center for Clinical and Research Informatics, North Shore University Health System, Evanston, IL 60201 (E-mail: ).Peter Müller, Department of Mathematics, University of Texas, Austin, TX 78712 (E-mail:…

用于局部聚类的非参数贝叶斯模型及其蛋白质组学应用AI 解读

We propose a nonparametric Bayesian local clustering (NoB-LoC) approach for heterogeneous data. NoB-LoC implements inference for nested clusters as posterior inference under a Bayesian model. Using protein expression data as an example, the NoB-LoC model defines a protein (column) cluster as a set of proteins that give rise to the same partition of the samples (rows). In other words, the sample partitions are nested within protein clusters. The common clustering of the…

非参数贝叶斯分析中的最小信息先验分布AI 解读

Summary We address the problem of how to conduct a minimally informative, non-parametric Bayesian analysis. The central question is how to devise a model so that the posterior distribution satisfies a few basic properties. The concept of ‘local mass’ provides the key to the development of the limiting Dirichlet process model. This model is then used to provide an engine for inference in the compound decision problem and for multiple-comparisons inference in a one-way…