Test of Significance for High-Dimensional Thresholds with Application to Individualized Minimal Clinically Important Difference
高维阈值参数的显著性检验:个体化最小临床重要差异应用
This work is motivated by learning the individualized minimal clinically important difference, a vital concept to assess clinical importance in various biomedical studies. We formulate the scientific question into a high-dimensional statistical problem where the parameter of interest lies in an individualized linear threshold. The goal is to develop a hypothesis testing procedure for the significance of a single element in this parameter as well as of a linear combination of…