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Double-Robust Small Area Estimation

小区域估计中的双重稳健方法

In the context of robust small area estimation (SAE), there are two types of robustness considerations, robustness against model misspecification and robustness against outliers. We propose a method of SAE that has both types of robustness features. The method combines the idea of observed best prediction (OBP), which is known to be more robust against model misspecification than the traditional best linear unbiased prediction (EBLUP) method, and the method of density power…

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Developing A Practical Measure: An Asymmetric Mean Squared Prediction Error for Small Area Estimation

小区域估计的实用度量:非对称均方预测误差

The mean squared prediction error (MSPE) is widely used in small area estimation (SAE), as well as in other fields of statistics. Despite its popularity, the MSPE is not always practical in that it treats positive error, or over-prediction, and negative error, or under-prediction, equally. In practice, however, the consequences of these two types of errors are often different. This problem has long been known in statistics; however, a practical solution has not received much…

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Asymptotic distribution of maximum likelihood estimator in generalized linear mixed models with crossed random effects

交叉随机效应广义线性混合模型中最大似然估计量的渐近分布

Generalized linear mixed models (GLMM) with crossed random effects is infamously known to present major challenges not only computationally but also theoretically. In fact, to date only consistency of the maximum likelihood estimators (MLE) has been proved for GLMM with crosses random effects. We introduce a new technique in asymptotic analysis built on a second-order Laplace approximation (LA) of a conditional expectation, whose coefficients are carefully evaluated. The LA…

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Classified Mixed Model Projections

分类混合模型投影

In many practical problems, there is interest in the estimation of mixed effect projections for new data that are outside the range of the training data. Examples include predicting extreme small area means for rare populations or making treatment decisions for patients who do not fit typical risk profiles. Standard methods have long been known to struggle with such problems since the training data may not provide enough information about potential model changes for these…

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Pseudo-Bayesian Classified Mixed Model Prediction

伪贝叶斯分类混合模型预测

We propose a new classified mixed model prediction (CMMP) procedure, called pseudo-Bayesian CMMP, that uses network information in matching the group index between the training data and new data, whose characteristics of interest one wishes to predict. The current CMMP procedures do not incorporate such information; as a result, the methods are not consistent in terms of matching the group index. Although, as the number of training data groups increases, the current CMMP…

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Usable and Precise Asymptotics for Generalized Linear Mixed Model Analysis and Design

广义线性混合模型分析与设计的可用精确渐近结果

Abstract We derive precise asymptotic results that are directly usable for confidence intervals and Wald hypothesis tests for likelihood-based generalized linear mixed model analysis. The essence of our approach is to derive the exact leading term behaviour of the Fisher information matrix when both the number of groups and number of observations within each group diverge. This leads to asymptotic normality results with simple studentizable forms. Similar analyses result in…

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Sumca: Simple, Unified, Monte-Carlo-assisted Approach to Second-Order Unbiased Mean-Squared Prediction Error Estimation

Sumca:蒙特卡洛辅助的二阶无偏均方预测误差估计

Summary We propose a simple, unified, Monte-Carlo-assisted approach (called ‘Sumca’) to second-order unbiased estimation of the mean-squared prediction error (MSPE) of a small area predictor. The MSPE estimator proposed is easy to derive, has a simple expression and applies to a broad range of predictors that include the traditional empirical best linear unbiased predictor, empirical best predictor and post-model-selection empirical best linear unbiased predictor and…

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Classified Mixed Model Prediction

基于类别匹配的混合模型预测

Many practical problems are related to prediction, where the main interest is at subject (e.g., personalized medicine) or (small) sub-population (e.g., small community) level. In such cases, it is possible to make substantial gains in prediction accuracy by identifying a class that a new subject belongs to. This way, the new subject is potentially associated with a random effect corresponding to the same class in the training data, so that method of mixed model prediction…

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On high-dimensional misspecified mixed model analysis in genome-wide association study

全基因组关联研究中高维误设混合模型的分析

We study behavior of the restricted maximum likelihood (REML) estimator under a misspecified linear mixed model (LMM) that has received much attention in recent genome-wide association studies. The asymptotic analysis establishes consistency of the REML estimator of the variance of the errors in the LMM, and convergence in probability of the REML estimator of the variance of the random effects in the LMM to a certain limit, which is equal to the true variance of the random…

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The E-MS Algorithm: Model Selection With Incomplete Data

E-MS 算法:不完整数据下的模型选择

We propose a procedure associated with the idea of the E-M algorithm for model selection in the presence of missing data. The idea extends the concept of parameters to include both the model and the parameters under the model, and thus allows the model to be part of the E-M iterations. We develop the procedure, known as the E-MS algorithm, under the assumption that the class of candidate models is finite. Some special cases of the procedure are considered, including E-MS…

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Best Predictive Small Area Estimation

最佳预测小域估计

We derive the best predictive estimator (BPE) of the fixed parameters under two well-known small area models, the Fay–Herriot model and the nested-error regression model. This leads to a new prediction procedure, called observed best prediction (OBP), which is different from the empirical best linear unbiased prediction (EBLUP). We show that BPE is more reasonable than the traditional estimators derived from estimation considerations, such as maximum likelihood (ML) and…

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Fence methods for mixed model selection

混合模型选择的围栏方法

Many model search strategies involve trading off model fit with model complexity in a penalized goodness of fit measure. Asymptotic properties for these types of procedures in settings like linear regression and ARMA time series have been studied, but these do not naturally extend to nonstandard situations such as mixed effects models, where simple definition of the sample size is not meaningful. This paper introduces a new class of strategies, known as fence methods, for…

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Iterative estimating equations: Linear convergence and asymptotic properties

迭代估计方程:线性收敛与渐近性质

We propose an iterative estimating equations procedure for analysis of longitudinal data. We show that, under very mild conditions, the probability that the procedure converges at an exponential rate tends to one as the sample size increases to infinity. Furthermore, we show that the limiting estimator is consistent and asymptotically efficient, as expected. The method applies to semiparametric regression models with unspecified covariances among the observations. In the…

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Estimation of Finite Population Domain Means

有限总体域均值的估计

In this article we introduce a general methodology for producing a model-assisted empirical best predictor (EBP) of a finite population domain mean using data from a complex survey. Our method improves on the commonly used design-consistent survey estimator by using a suitable mixed model. Such a model combines information from related sources, such as census and administrative data. Unlike a purely model-based EBP, the proposed model-assisted EBP converges in probability to…

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Partially observed information and inference about non-Gaussian mixed linear models

非高斯线性混合模型的部分观测信息与推断

In mixed linear models with nonnormal data, the Gaussian Fisher information matrix is called a quasi-information matrix (QUIM). The QUIM plays an important role in evaluating the asymptotic covariance matrix of the estimators of the model parameters, including the variance components. Traditionally, there are two ways to estimate the information matrix: the estimated information matrix and the observed one. Because the analytic form of the QUIM involves parameters other than…

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Mean squared error of empirical predictor

经验预测量的均方误差

The term “empirical predictor” refers to a two-stage predictor of a linear combination of fixed and random effects. In the first stage, a predictor is obtained but it involves unknown parameters; thus, in the second stage, the unknown parameters are replaced by their estimators. In this paper, we consider mean squared errors (MSE) of empirical predictors under a general setup, where ML or REML estimators are used for the second stage. We obtain second-order approximation to…

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A unified jackknife theory for empirical best prediction with M-estimation

基于 M 估计的经验最优预测统一刀切理论

The paper presents a unified jackknife theory for a fairly general class of mixed models which includes some of the widely used mixed linear models and generalized linear mixed models as special cases. The paper develops jackknife theory for the important, but so far neglected, prediction problem for the general mixed model. For estimation of fixed parameters, a jackknife method is considered for a general class of M-estimators which includes the maximum likelihood, residual…

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Goodness-of-fit tests for mixed model diagnostics

用于混合模型诊断的拟合优度检验

A simple goodness of fit test is proposed for checking distributional assumptions involved in a mixed linear model. An estimated critical value of the test statistic is derived, and is shown to be asymptotically correct under mild conditions. As a special case,the test may be applied to linear regression models to formally check distribution of the errors. Finite sample performance of the proposed test is examined and compared with that of a previously proposed test by…

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Conditional inference about generalized linear mixed models

广义线性混合模型的条件推断

We propose a method of inference for generalized linear mixed models (GLMM) that in many ways resembles the method of least squares. We also show that adequate inference about GLMM can be made based on the conditional likelihood on a subset of the random effects. One of the important features of our methods is that they rely on weak distributional assumptions about the random effects. The methods proposed are also computationally feasible. Asymptotic behavior of the…

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A Test for Global Maximum

全局最大值的检验

We give simple necessary and sufficient conditions for consistency and asymptotic optimality of a root to the likelihood equation. Based on the results, a large-sample test is proposed for detecting whether a given root is consistent and asymptotically efficient, a property often possessed by the global maximizer of the likelihood function. A number of examples, and the connection between the proposed test and the test of White for model misspecification, are discussed.…

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A Test for Global Maximum

关于全局最大值的检验

We give simple necessary and sufficient conditions for consistency and asymptotic optimality of a root to the likelihood equation. Based on the results, a large-sample test is proposed for detecting whether a given root is consistent and asymptotically efficient, a property often possessed by the global maximizer of the likelihood function. A number of examples, and the connection between the proposed test and the test of White for model misspecification, are discussed.…

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Consistent Estimators in Generalized Linear Mixed Models

广义线性混合模型中的一致估计量

A simple method based on simulated moments is proposed for estimating the fixed-effects and variance components in a generalized linear mixed model (GLMM). It is shown that the method is not only computationally attractive but also leads to consistent estimators. On the other hand, simulation shows that the method can be quite inefficient.

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Wald consistency and the method of sieves in REML estimation

REML估计中的Wald一致性与筛方法

We prove that for all unconfounded balanced mixed models of the analysis of variance, estimates of variance components parameters that maximize the (restricted) Gaussian likelihood are consistent and asymptotically normal--and this is true whether normality is assumed or not. For a general (nonnormal) mixed model, we show estimates of the variance components parameters that maximize the (restricted) Gaussian likelihood over a sequence of approximating parameter spaces (i.e.,…

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REML estimation: asymptotic behavior and related topics

REML 估计:渐近行为及相关问题

The restricted maximum likelihood (REML) estimates of dispersion parameters (variance components) in a general (non-normal) mixed model are defined as solutions of the REML equations. In this paper, we show the REML estimates are consistent if the model is asymptotically identifiable and infinitely informative under the (location) invariant class, and are asymptotically normal (A.N.) if in addition the model is asymptotically nondegenerate. The result does not require…

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