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临床试验中应答及应答持续时间的截断几何模型AI 解读

For treatment comparisons in clinical cancer trials, the data often indicate absence or presence of response along with duration of response when it occurs. Response length is frequently truncated by death, loss of followup information, study termination, or other causes, and is usually a discrete variable (days, weeks, or months). A mixture of a binomial and truncated geometric probability is studied as an appropriate statistical model. Maximum likelihood estimators are…

临床试验中的截断几何响应与响应持续时间模型AI 解读

For treatment comparisons in clinical cancer trials, the data often indicate absence or presence of response along with duration of response when it occurs. Response length is frequently truncated by death, loss of followup information, study termination, or other causes, and is usually a discrete variable (days, weeks, or months). A mixture of a binomial and truncated geometric probability is studied as an appropriate statistical model. Maximum likelihood estimators are…