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昂贵协变量的响应依赖抽样关联得分检验AI 解读

Response-dependent sampling is widely used in settings where certain variables are expensive to obtain. Estimation has been thoroughly investigated but recent applications have emphasized tests of association for expensive covariates and a response variable. We consider testing and provide easily implemented likelihood score tests for generalized linear models under a broad range of sampling plans. We show that when there are no additional covariates, the score statistics…

事件依赖删失与终止下复发事件均值函数及治疗效应的稳健估计AI 解读

In clinical trials featuring recurrent clinical events, the definition and estimation of treatment effects involves a number of interesting issues, especially when loss to follow-up may be event-related and when terminal events such as death preclude the occurrence of further events. This paper discusses a clinical trial of breast cancer patients with bone metastases where the recurrent events are skeletal complications, and where patients may die during the trial. We argue…

回归分析中的二元位置—尺度模型及寿命数据应用AI 解读

Summary The literature on multivariate linear regression includes multivariate normal models, models that are used in survival analysis and a variety of models that are used in other areas such as econometrics. The paper considers the class of location–scale models, which includes a large proportion of the preceding models. It is shown that, for complete data, the maximum likelihood estimators for regression coefficients in a linear location–scale framework are consistent…

截断重复事件数据的发生率与均值函数估计AI 解读

This article investigates data on recurrent events that arise from sources such as warranty claims, where the observation period for a unit is unknown until it experiences at least one event. This creates a type of truncation in the data. We consider nonparametric estimation of means and rates of the event occurrences with such “zero-truncated” data and examine the case where the population size and the distribution of observation times across units are at least…