Bayes Methods for Combining the Results of Cancer Studies in Humans and other Species
结合人类与其他物种癌症研究结果的贝叶斯方法
We propose a class of Bayesian statistical methods for interspecies extrapolation of dose-response functions. The methods distinguish formally between the conventional sampling error within each dose-response experiment and a novel error of uncertain relevance between experiments. Through a system of hierarchical prior distributions similar to that of Lindley and Smith (1972), the dose-response data from many substances and species are used to estimate the interexperimental…