Multiple Test Procedures for Identifying the Maximum Safe Dose
识别最大安全剂量的多重检验程序
We consider dose response studies for safety assessment of crop protection compounds and drugs, and we offer a hypothesis testing approach for identifying the maximum dose level that is guaranteed to be safe with preassigned confidence. The focus is on step-down (SD) multiple test procedures for identifying the maximum safe dose. We propose two classes of contrasts among the dose means as test statistics for these procedures: pairwise contrasts (PC) and Helmert contrasts…