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Semiparametric fiducial inference for Cox models

Cox 模型的半参数 Fiducial 推断

Abstract R.A. Fisher introduced the fiducial distribution as a potential replacement for the Bayesian posterior distribution in the 1930s. During the past century, fiducial approaches have been explored in various parametric and nonparametric settings. However, to the best of our knowledge, no fiducial inference has been developed in the realm of semiparametric statistics. In this paper, we propose a novel fiducial approach for semiparametric models. In memory of Sir David…

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A Unified Nonparametric Fiducial Approach to Interval-Censored Data

区间删失数据的统一非参数 fiducial 推断

Censored data, where the event time is partially observed, are challenging for survival probability estimation. In this article, we introduce a novel nonparametric fiducial approach to interval-censored data, including right-censored, current status, case II censored, and mixed case censored data. The proposed approach leveraging a simple Gibbs sampler has a useful property of being “one size fits all,” that is, the proposed approach automatically adapts to all types of…

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A Bayesian Approach to Multistate Hidden Markov Models: Application to Dementia Progression

多状态隐马尔可夫模型的贝叶斯方法:痴呆进展应用

People are living longer than ever before, and with this arises new complications and challenges for humanity. Among the most pressing of these challenges is of understanding the role of aging in the development of dementia. This article is motivated by the Mayo Clinic Study of Aging data for 4742 subjects since 2004, and how it can be used to draw inference on the role of aging in the development of dementia. We construct a hidden Markov model (HMM) to represent progression…

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Nonpenalized variable selection in high-dimensional linear model settings via generalized fiducial inference

通过广义信赖推断进行高维线性模型的非惩罚变量选择

Standard penalized methods of variable selection and parameter estimation rely on the magnitude of coefficient estimates to decide which variables to include in the final model. However, coefficient estimates are unreliable when the design matrix is collinear. To overcome this challenge, an entirely new perspective on variable selection is presented within a generalized fiducial inference framework. This new procedure is able to effectively account for linear dependencies…

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Generalized Fiducial Inference: A Review and New Results

广义信赖推断:综述与新结果

R. A. Fisher, the father of modern statistics, proposed the idea of fiducial inference during the first half of the 20th century. While his proposal led to interesting methods for quantifying uncertainty, other prominent statisticians of the time did not accept Fisher’s approach as it became apparent that some of Fisher’s bold claims about the properties of fiducial distribution did not hold up for multi-parameter problems. Beginning around the year 2000, the authors and…

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Generalized Fiducial Inference for Ultrahigh-Dimensional Regression

超高维回归的广义信赖推断

In recent years, the ultrahigh-dimensional linear regression problem has attracted enormous attention from the research community. Under the sparsity assumption, most of the published work is devoted to the selection and estimation of the predictor variables with nonzero coefficients. This article studies a different but fundamentally important aspect of this problem: uncertainty quantification for parameter estimates and model choices. To be more specific, this article…

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Generalized fiducial inference for normal linear mixed models

正态线性混合模型的广义 fiducial 推断

While linear mixed modeling methods are foundational concepts introduced in any statistical education, adequate general methods for interval estimation involving models with more than a few variance components are lacking, especially in the unbalanced setting. Generalized fiducial inference provides a possible framework that accommodates this absence of methodology. Under the fabric of generalized fiducial inference along with sequential Monte Carlo methods, we present an…

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Fiducial Intervals for Variance Components in an Unbalanced Two-Component Normal Mixed Linear Model

非平衡双分量正态混合线性模型中方差分量的信赖区间

In this article we propose a new method for constructing confidence intervals for σα2,σϵ2, and the intraclass correlation ρ==σα2(σα2++σε2) in a two-component mixed-effects linear model. This method is based on an extension of R. A. Fisher's fiducial argument. We conducted a simulation study to compare the resulting interval estimates with other competing confidence interval procedures from the literature. Our results demonstrate that the proposed fiducial intervals have…

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Fiducial Generalized Confidence Intervals

基于 Fiducial 枢轴量的广义置信区间

Generalized pivotal quantities (GPQs) and generalized confidence intervals (GCIs) have proven to be useful tools for making inferences in many practical problems. Although GCIs are not guaranteed to have exact frequentist coverage, a number of published and unpublished simulation studies suggest that the coverage probabilities of such intervals are sufficiently close to their nominal value so as to be useful in practice. In this article we single out a subclass of…

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