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临床试验重复测量的序贯秩检验AI 解读

For comparing responses in two groups of subjects observed repeatedly, we propose a group sequential procedure based on linear rank statistics. The asymptotic normality of the sequentially computed linear rank statistics is obtained, and construction of the group sequential boundaries is based on this distribution theory. By virtue of this asymptotic approximation, the proposed procedure can be applied to interim analyses with either continuous or discrete repeated…

重复测量数据中变化速率的序贯比较AI 解读

There are many clinical trials in which the patients enter sequentially, and a response variable is measured repeatedly over time for each patient. A group sequential procedure is proposed for comparing the rates of change between two treatment groups. Some existing procedures for testing the equality of means between two treatment groups with repeated measurements data, such as those proposed by Armitage, Stratton, and Worthington and by Geary, can be interpreted as special…