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分类混合模型投影AI 解读

In many practical problems, there is interest in the estimation of mixed effect projections for new data that are outside the range of the training data. Examples include predicting extreme small area means for rare populations or making treatment decisions for patients who do not fit typical risk profiles. Standard methods have long been known to struggle with such problems since the training data may not provide enough information about potential model changes for these…

基于类别匹配的混合模型预测AI 解读

Many practical problems are related to prediction, where the main interest is at subject (e.g., personalized medicine) or (small) sub-population (e.g., small community) level. In such cases, it is possible to make substantial gains in prediction accuracy by identifying a class that a new subject belongs to. This way, the new subject is potentially associated with a random effect corresponding to the same class in the training data, so that method of mixed model prediction…

E-MS 算法：不完整数据下的模型选择AI 解读

We propose a procedure associated with the idea of the E-M algorithm for model selection in the presence of missing data. The idea extends the concept of parameters to include both the model and the parameters under the model, and thus allows the model to be part of the E-M iterations. We develop the procedure, known as the E-MS algorithm, under the assumption that the class of candidate models is finite. Some special cases of the procedure are considered, including E-MS…

最佳预测小域估计AI 解读

We derive the best predictive estimator (BPE) of the fixed parameters under two well-known small area models, the Fay–Herriot model and the nested-error regression model. This leads to a new prediction procedure, called observed best prediction (OBP), which is different from the empirical best linear unbiased prediction (EBLUP). We show that BPE is more reasonable than the traditional estimators derived from estimation considerations, such as maximum likelihood (ML) and…

混合模型选择的围栏方法AI 解读

Many model search strategies involve trading off model fit with model complexity in a penalized goodness of fit measure. Asymptotic properties for these types of procedures in settings like linear regression and ARMA time series have been studied, but these do not naturally extend to nonstandard situations such as mixed effects models, where simple definition of the sample size is not meaningful. This paper introduces a new class of strategies, known as fence methods, for…

最高后验概率模型选择的深入考察AI 解读

We consider the properties of the highest posterior probability model in a linear regression setting. Under a spike and slab hierarchy we find that although highest posterior model selection is total risk consistent, it possesses hidden undesirable properties. One such property is a marked underfitting in finite samples, a phenomenon well noted for Bayesian information criterion (BIC) related procedures but not often associated with highest posterior model selection. Another…

多组微阵列数据的尖峰与厚尾基因选择AI 解读

DNA microarrays can provide insight into genetic changes that characterize different stages of a disease process. Accurate identification of these changes has significant therapeutic and diagnostic implications. Statistical analysis for multistage (multigroup) data is challenging, however. ANOVA-based extensions of two-sample Z-tests, a popular method for detecting differentially expressed genes in two groups, do not work well in multigroup settings. False detection rates…

基于尖峰—平板先验的变量选择：频率学派与贝叶斯策略AI 解读

Variable selection in the linear regression model takes many apparent faces from both frequentist and Bayesian standpoints. In this paper we introduce a variable selection method referred to as a rescaled spike and slab model. We study the importance of prior hierarchical specifications and draw connections to frequentist generalized ridge regression estimation. Specifically, we study the usefulness of continuous bimodal priors to model hypervariance parameters, and the…

利用贝叶斯模型选择识别微阵列中的差异表达基因AI 解读

DNA microarrays open up a broad new horizon for investigators interested in studying the genetic determinants of disease. The high throughput nature of these arrays, where differential expression for thousands of genes can be measured simultaneously, creates an enormous wealth of information, but also poses a challenge for data analysis because of the large multiple testing problem involved. The solution has generally been to focus on optimizing false-discovery rates while…