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残留效应与直接效应成比例时的最优交叉设计AI 解读

There are a number of different models for crossover designs which take account of carryover effects. Since it seems plausible that a treatment with a large direct effect should generally have a larger carryover effect, Kempton et al. (2001) considered a model where the carryover effects are proportional to the direct effects. The advantage of this model lies in the fact that there are fewer parameters to be estimated. Its problem lies in the nonlinearity of the estimators.…

交叉设计中的方差估计AI 解读

SUMMARY There is concern that the usual analysis of crossover designs with more than two treatments is subject to bias due to correlations between the measurements on the same experimental units. It has been shown by Kunert in the special case of balanced Latin squares that this bias can be present but that it is limited. Extending the work of Kunert we show in the present paper that there is a constant X* which guarantees that the estimate for the variance of any treatment…