Miscellanea. A stopping rule for the continual reassessment method
短论：持续再评估方法的停止规则
The continual reassessment method provides a new approach for estimating the maximum tolerated dose in a phase I clinical trial. In this paper we investigate a potential stopping rule for this method. We indicate certain situations in which the finally chosen dose level can be predicted with certainty after having included a number of patients strictly less than the projected sample size. There is therefore a clear gain when the only purpose of the trial is to identify a…