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对归一化常数难以计算的分布进行抽样的自适应交换算法AI 解读

Sampling from the posterior distribution for a model whose normalizing constant is intractable is a long-standing problem in statistical research. We propose a new algorithm, adaptive auxiliary variable exchange algorithm, or, in short, adaptive exchange (AEX) algorithm, to tackle this problem. The new algorithm can be viewed as a MCMC extension of the exchange algorithm, which generates auxiliary variables via an importance sampling procedure from a Markov chain running in…

用数据增广支持结局延迟的一至二期临床试验AI 解读

A practical impediment in adaptive clinical trials is that outcomes must be observed soon enough to apply decision rules to choose treatments for new patients. For example, if outcomes take up to six weeks to evaluate and the accrual rate is one patient per week, on average three new patients will be accrued while waiting to evaluate the outcomes of the previous three patients. The question is how to treat the new patients. This logistical problem persists throughout the…