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存在隐变量的高维多响应回归推断AI 解读

This article studies the inference of the regression coefficient matrix under multivariate response linear regressions in the presence of hidden variables. A novel procedure for constructing confidence intervals of entries of the coefficient matrix is proposed. Our method first uses the multivariate nature of the responses by estimating and adjusting the hidden effect to construct an initial estimator of the coefficient matrix. By further deploying a low-dimensional…

高维阈值参数的显著性检验：个体化最小临床重要差异应用AI 解读

This work is motivated by learning the individualized minimal clinically important difference, a vital concept to assess clinical importance in various biomedical studies. We formulate the scientific question into a high-dimensional statistical problem where the parameter of interest lies in an individualized linear threshold. The goal is to develop a hypothesis testing procedure for the significance of a single element in this parameter as well as of a linear combination of…

二元响应下高维个体化阈值的非正则与极小极大估计AI 解读

Given a large number of covariates Z, we consider the estimation of a high-dimensional parameter θ in an individualized linear threshold θTZ for a continuous variable X, which minimizes the disagreement between sign(X−θTZ) and a binary response Y. While the problem can be formulated into the M-estimation framework, minimizing the corresponding empirical risk function is computationally intractable due to discontinuity of the sign function. Moreover, estimating θ even in the…