A Tailored Multivariate Mixture Model for Detecting Proteins of Concordant Change Among Virulent Strains of Clostridium Perfringens
识别产气荚膜梭菌致病菌株间一致变化蛋白的定制多元混合模型
Necrotic enteritis (NE) is a serious disease of poultry caused by the bacterium C. perfringens. To identify proteins of C. perfringens that confer virulence with respect to NE, the protein secretions of four NE disease-producing strains and one baseline nondisease-producing strain of C. perfringens were examined. The problem then becomes a clustering task, for the identification of two extreme groups of proteins that were produced at either concordantly higher or…