Nonparametric Estimation of the Hazard Ratio
风险率比的非参数估计
A nonparametric estimate of the hazard ratio function is developed and applied to the time-dependent survival advantage of having achieved an objective response to treatment for a given disease. The method computes the total exposure to risk of failure, or dying, among patients in either of two disease states (nonresponder/responder). By assuming constant hazard rates between observed failure times, and using smoothing techniques of exploratory data analysis, the log hazard…