Statistical Analysis of Ion Channel Data Using Hidden Markov Models With Correlated State-Dependent Noise and Filtering
含相关状态依赖噪声与滤波效应的离子通道隐马尔可夫分析
A hidden Markov model that describes ion channel data, including correlated, state-dependent noise and filter characteristics, and a Markov chain Monte Carlo algorithm that enables Bayesian inference under this model are presented. The method provides parameter estimates and an estimate of the noiseless signal. It was tested on simulated data and applied to real recordings to estimate the model parameters. Modeling the noise and filter correctly turned out to be crucial for…