A Marginal Approach to Reduced-Rank Penalized Spline Smoothing With Application to Multilevel Functional Data
降秩惩罚样条平滑的边际方法及其多层函数数据应用
Multilevel functional data is collected in many biomedical studies. For example, in a study of the effect of Nimodipine on patients with subarachnoid hemorrhage (SAH), patients underwent multiple 4-hour treatment cycles. Within each treatment cycle, subjects' vital signs were reported every 10 minutes. This data has a natural multilevel structure with treatment cycles nested within subjects and measurements nested within cycles. Most literature on nonparametric analysis of…