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Fixed Effects Testing in High-Dimensional Linear Mixed Models

高维线性混合模型中的固定效应检验

Many scientific and engineering challenges—ranging from pharmacokinetic drug dosage allocation and personalized medicine to marketing mix (4Ps) recommendations—require an understanding of the unobserved heterogeneity to develop the best decision making-processes. In this article, we develop a hypothesis test and the corresponding p-value for testing for the significance of the homogeneous structure in linear mixed models. A robust matching moment construction is used for…

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Macro-Economic Factors in Credit Risk Calculations: Including Time-Varying Covariates in Mixture Cure Models

信用风险计算中的宏观因素:混合治愈模型中的时变协变量

The prediction of the time of default in a credit risk setting via survival analysis needs to take a high censoring rate into account. This rate is because default does not occur for the majority of debtors. Mixture cure models allow the part of the loan population that is unsusceptible to default to be modeled, distinct from time of default for the susceptible population. In this article, we extend the mixture cure model to include time-varying covariates. We illustrate the…

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Asymptotic post-selection inference for the Akaike information criterion

Akaike 信息准则的渐近选择后推断

Ignoring the model selection step in inference after selection is harmful. In this paper we study the asymptotic distribution of estimators after model selection using the Akaike information criterion. First, we consider the classical setting in which a true model exists and is included in the candidate set of models. We exploit the overselection property of this criterion in constructing a selection region, and we obtain the asymptotic distribution of estimators and linear…

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A Multiresolution Approach to Time Warping Achieved by a Bayesian Prior–Posterior Transfer Fitting Strategy

通过贝叶斯先验—后验转移拟合实现时间扭曲的多分辨率方法

Summary Warping is an approach to the reduction and analysis of phase variability in functional observations, by applying a smooth bijection to the function argument. We propose a natural representation of warping functions in terms of a new type of elementary functions named ‘warping component functions’, or ‘warplets’, which are combined into the warping function by composition. The inverse warping function is trivial and explicit to obtain. A sequential Bayesian…

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Simultaneous Confidence Bands for Penalized Spline Estimators

惩罚样条估计的同时置信带

In this article we construct simultaneous confidence bands for a smooth curve using penalized spline estimators. We consider three types of estimation methods: (a) as a standard (fixed effect) nonparametric model, (b) using the mixed-model framework with the spline coefficients as random effects, and (c) a full Bayesian approach. The volume-of-tube formula is applied for the first two methods and compared with Bayesian simultaneous confidence bands from a frequentist…

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Testing for Lack of Fit in Inverse Regression—with Applications to Biophotonic Imaging

逆回归中的失拟检验及其生物光子成像应用

Summary We propose two test statistics for use in inverse regression problems Y = Kθ+ε, where K is a given linear operator which cannot be continuously inverted. Thus, only noisy, indirect observations Y for the function θ are available. Both test statistics have a counterpart in classical hypothesis testing, where they are called the order selection test and the data-driven Neyman smooth test. We also introduce two model selection criteria which extend the classical Akaike…

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MINIMIZING AVERAGE RISK IN REGRESSION MODELS

回归模型中平均风险的最小化

Most model selection mechanisms work in an “overall” modus, providing models without specific concern for how the selected model is going to be used afterward. The focused information criterion (FIC), on the other hand, is geared toward optimum model selection when inference is required for a given estimand. In this paper the FIC method is extended to weighted versions. This allows one to rank and select candidate models for the purpose of handling a range of similar tasks…

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Focused Information Criteria and Model Averaging for the Cox Hazard Regression Model

Cox 风险回归模型的聚焦信息准则与模型平均

This article is concerned with variable selection methods for the Cox proportional hazards regression model. Including excessive covariates causes extra variability and inflated confidence intervals for regression parameters; thus regimes for discarding the less informative ones are needed. Our framework has p covariates designated as “protected,” while variables from a further set of q covariates are examined for possible inclusion or exclusion. We develop a focused…

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Exact likelihood ratio tests for penalised splines

惩罚样条的精确似然比检验

Penalised-spline-based additive models allow a simple mixed model representation where the variance components control departures from linear models. The smoothing parameter is the ratio of the random-coefficient and error variances and tests for linear regression reduce to tests for zero random-coefficient variances. We propose exactlikelihood and restricted likelihood ratio tests for testing polynomial regression versus a general alternative modelled by penalised splines.…

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Bayesian-motivated tests of function fit and their asymptotic frequentist properties

贝叶斯动机的函数拟合检验及其渐近频率学性质

We propose and analyze nonparametric tests of the null hypothesis that a function belongs to a specified parametric family. The tests are based on BIC approximations, πBIC, to the posterior probability of the null model, and may be carried out in either Bayesian or frequentist fashion. We obtain results on the asymptotic distribution of πBIC under both the null hypothesis and local alternatives. One version of πBIC, call it π*BIC, uses a class of models that are orthogonal…

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Restricted Likelihood Ratio Lack-of-Fit Tests Using Mixed Spline Models

利用混合样条模型进行限制似然比失拟检验

Summary Penalized regression spline models afford a simple mixed model representation in which variance components control the degree of non-linearity in the smooth function estimates. This motivates the study of lack-of-fit tests based on the restricted maximum likelihood ratio statistic which tests whether variance components are 0 against the alternative of taking on positive values. For this one-sided testing problem a further complication is that the variance component…

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Bootstrap confidence bands for regression curves and their derivatives

回归曲线及其导数的自助法置信带

Confidence bands for regression curves and their first p derivatives are obtained via local pth order polynomial estimation. The method allows for multiparameter local likelihood estimation as well as other unbiased estimating equations. As an alternative to the confidence bands obtained by asymptotic distribution theory, we also study smoothed bootstrap confidence bands. Simulations illustrate the finite sample properties of the methodology.

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Frequentist Model Average Estimators

频率学派模型平均估计量

The traditional use of model selection methods in practice is to proceed as if the final selected model had been chosen in advance, without acknowledging the additional uncertainty introduced by model selection. This often means underreporting of variability and too optimistic confidence intervals. We build a general large-sample likelihood apparatus in which limiting distributions and risk properties of estimators post-selection as well as of model average estimators are…

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The Focused Information Criterion

聚焦信息准则

A variety of model selection criteria have been developed, of general and specific types. Most of these aim at selecting a single model with good overall properties, for example, formulated via average prediction quality or shortest estimated overall distance to the true model. The Akaike, the Bayesian, and the deviance information criteria, along with many suitable variations, are examples of such methods. These methods are not concerned, however, with the actual use of the…

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Effect of dependence on stochastic measures of accuracy of density estimations

依赖性对密度估计随机精度度量的影响

In kernel density estimation, those data values that make a nondegenerate contribution to the estimator (computed at a given point) tend to be spaced well apart. This property has the effect of suppressing many of the conventional consequences of long-range dependence, for example, slower rates of convergence, which might otherwise be revealed by a traditional loss-or risk-based assessment of performance. From that viewpoint, dependence has to be very long-range indeed…

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Testing the Fit of a Parametric Function

参数函数的拟合检验

General methods for testing the fit of a parametric function are proposed. The idea underlying each method is to “accept” the prescribed parametric model if and only if it is chosen by a model selection criterion. Several different selection criteria are considered, including one based on a modified version of the Akaike information criterion and others based on various score statistics. The tests have a connection with nonparametric smoothing because they use orthogonal…

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Local Polynomial Estimation in Multiparameter Likelihood Models

多参数似然模型中的局部多项式估计

The nonparametric regression technique of local polynomial fitting is extended to multiparameter likelihood models. Some well-known appealing features of local polynomial smoothers, such as the behavior at the boundary, are shown to carry over to the multiparameter case. Asymptotic consistency and normality of the resulting estimators are derived under suitable regularity conditions. This work is motivated by the need for a nonparametric alternative to parametric…

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