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等位基因丢失频率数据的贝叶斯分析AI 解读

One objective of allelic-loss studies is to identify chromosomal locations that may harbor tumor-suppressor genes. An instability-selection model has been developed for allelic-loss data in which the loss events are available for each tumor and each marker (allelotypes). In performing pooled analyses of published allelic-loss experiments, however, only summaries of the frequency of allelic loss (FAL) may be available. The instability-selection model can be applied to these…

利用奇异值分解估计寡核苷酸阵列的表达指数AI 解读

Multiprobe oligonucleotide arrays are a widely used type of expression microarray with the attractive feature that numerous probes are used to represent each transcript. An “expression index” is a statistic used to represent expression level for a particular gene that is estimated from the probe hybridization intensities. We show that a popular model-based expression index proposed by Li and Wong has an interpretation as a component of the singular value decomposition (SVD)…