A Bayesian Hierarchical Model for Analysis of Single-Nucleotide Polymorphisms Diversity in Multilocus, Multipopulation Samples
多位点、多种群样本中单核苷酸多态性多样性的贝叶斯层级模型
The distribution of genetic variation among populations is conveniently measured by Wright's F(ST), which is a scaled variance taking on values in [0,1]. For certain types of genetic markers, and for single-nucleotide polymorphisms (SNPs) in particular, it is reasonable to presume that allelic differences at most loci are selectively neutral. For such loci, the distribution of genetic variation among populations is determined by the size of local populations, the pattern and…