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离散对数凹最大似然估计的渐近理论及应用AI 解读

Summary The assumption of log-concavity is a flexible and appealing non-parametric shape constraint in distribution modelling. In this work, we study the log-concave maximum likelihood estimator of a probability mass function. We show that the maximum likelihood estimator is strongly consistent and we derive its pointwise asymptotic theory under both the well-specified and misspecified settings. Our asymptotic results are used to calculate confidence intervals for the true…

大肠杆菌 SecYEG 孔道的单通道与多通道电流：含噪观测的模态数检验AI 解读

We analyze a new dataset from an electrophysiological recording of transmembrane currents through a bacterial membrane channel to demonstrate the existence of single and multiple channel currents. Protein channels mediate transport through biological membranes; knowledge of the channel properties gained from electrophysiological recordings is important for a targeted drug design. We investigate the bacterial membrane protein SecYEG which is of essential importance for the…

对数凹密度最大似然估计的极限分布理论AI 解读

We find limiting distributions of the nonparametric maximum likelihood estimator (MLE) of a log-concave density, i.e. a density of the form f(0) = exp varphi(0) where varphi(0) is a concave function on R. Existence, form, characterizations and uniform rates of convergence of the MLE are given by Rufibach (2006) and Dümbgen and Rufibach (2007). The characterization of the log-concave MLE in terms of distribution functions is the same (up to sign) as the characterization of…

k 单调密度估计：极限分布理论与样条联系AI 解读

We study the asymptotic behavior of the Maximum Likelihood and Least Squares Estimators of a k-monotone density g0 at a fixed point x0 when k>2. We find that the jth derivative of the estimators at x0 converges at the rate n−(k−j)/(2k+1) for j=0, …, k−1. The limiting distribution depends on an almost surely uniquely defined stochastic process Hk that stays above (below) the k-fold integral of Brownian motion plus a deterministic drift when k is even (odd). Both the MLE and…

概率预测、校准与集中度AI 解读

Summary Probabilistic forecasts of continuous variables take the form of predictive densities or predictive cumulative distribution functions. We propose a diagnostic approach to the evaluation of predictive performance that is based on the paradigm of maximizing the sharpness of the predictive distributions subject to calibration. Calibration refers to the statistical consistency between the distributional forecasts and the observations and is a joint property of the…