Optimal designs for the emax, log-linear and exponential models
emax、对数线性与指数模型的最优设计
We derive locally D- and EDp-optimal designs for the exponential, log-linear and three-parameter emax models. For each model the locally D- and EDp-optimal designs are supported at the same set of points, while the corresponding weights are different. This indicates that for a given model, D-optimal designs are efficient for estimating the smallest dose that achieves 100p% of the maximum effect in the observed dose range. Conversely, EDp-optimal designs also yield good…