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右删失事件时间预测集的双重稳健高效校准AI 解读

Abstract Our objective is to construct well-calibrated prediction sets for a time-to-event outcome subject to right censoring with guaranteed coverage. Inspired by modern conformal inference, our approach avoids the need for a well-specified parametric or semiparametric survival model. Unlike existing conformal methods for survival data, which assume Type-I censoring with fully observed censoring times, we consider the more common right-censoring setting in which only the…

合成控制的识别与推断：近端因果推断框架AI 解读

Synthetic control (SC) methods are commonly used to estimate the treatment effect on a single treated unit in panel data settings. An SC is a weighted average of control units built to match the treated unit, with weights typically estimated by regressing pre-treatment outcomes and measured covariates of the treated unit to those of the control units. However, the classical SC method was primarily proposed for empirical settings where a good pre-treatment fit is attainable…

含潜在中介变量的因果推断AI 解读

Summary Proximal causal inference was recently proposed as a framework to identify causal effects from observational data in the presence of hidden confounders for which proxies are available. In this paper, we extend the proximal causal inference approach to settings where identification of causal effects hinges upon a set of mediators that are not observed, yet error prone proxies of the hidden mediators are measured. Specifically, (i) we establish causal hidden mediation…

GENIUS-MAWII：应对大量弱且无效工具变量的稳健孟德尔随机化AI 解读

Abstract Mendelian randomization (MR) addresses causal questions using genetic variants as instrumental variables. We propose a new MR method, G-Estimation under No Interaction with Unmeasured Selection (GENIUS)-MAny Weak Invalid IV, which simultaneously addresses the 2 salient challenges in MR: many weak instruments and widespread horizontal pleiotropy. Similar to MR-GENIUS, we use heteroscedasticity of the exposure to identify the treatment effect. We derive influence…

协变量漂移下预测集的双重稳健校准AI 解读

Abstract Conformal prediction has received tremendous attention in recent years and has offered new solutions to problems in missing data and causal inference; yet these advances have not leveraged modern semi-parametric efficiency theory for more efficient uncertainty quantification. We consider the problem of obtaining well-calibrated prediction regions that can data adaptively account for a shift in the distribution of covariates between training and test data. Under a…

一般数据集偏移下的高效且多重稳健风险估计AI 解读

. Despite extensive literature on dataset shift, limited works address how to efficiently use the auxiliary populations to improve the accuracy of risk evaluation for a given machine learning task in the target population. In this paper, we study the general problem of efficiently estimating target population risk under various dataset shift conditions, leveraging semiparametric efficiency theory. We consider a general class of dataset shift conditions, which includes three…

半参数近端因果推断AI 解读

Skepticism about the assumption of no unmeasured confounding, also known as exchangeability, is often warranted in making causal inferences from observational data; because exchangeability hinges on an investigator's ability to accurately measure covariates that capture all potential sources of confounding.In practice, the most one can hope for is that covariate measurements are at best proxies of the true underlying confounding mechanism operating in a given observational…

适应未知协变量分布漂移的预测集AI 解读

Abstract Predicting sets of outcomes—instead of unique outcomes—is a promising solution to uncertainty quantification in statistical learning. Despite a rich literature on constructing prediction sets with statistical guarantees, adapting to unknown covariate shift—a prevalent issue in practice—poses a serious unsolved challenge. In this article, we show that prediction sets with finite-sample coverage guarantee are uninformative and propose a novel flexible…

不识别联合分布时非可忽略无应答数据的均值泛函推断AI 解读

Abstract We consider identification and inference about mean functionals of observed covariates and an outcome variable subject to non-ignorable missingness. By leveraging a shadow variable, we establish a necessary and sufficient condition for identification of the mean functional even if the full data distribution is not identified. We further characterize a necessary condition for n-estimability of the mean functional. This condition naturally strengthens the identifying…

疫苗有效性检测阴性设计研究中的双负对照推断AI 解读

The test-negative design (TND) has become a standard approach to evaluate vaccine effectiveness against the risk of acquiring infectious diseases in real-world settings, such as Influenza, Rotavirus, Dengue fever, and more recently COVID-19. In a TND study, individuals who experience symptoms and seek care are recruited and tested for the infectious disease which defines cases and controls. Despite TND's potential to reduce unobserved differences, in healthcare seeking…

反事实世界中的个体化决策机器智能：作者回复AI 解读

This JASA rejoinder concerns the problem of individualized decision making under point, sign, and partial identification. The paper unifies various classical decision making strategies through a lower bound perspective proposed in Cui and Tchetgen Tchetgen (2020b) in the context of optimal treatment regimes under uncertainty due to unmeasured confounding. Building on this unified framework, the paper also provides a novel minimax solution (i.e., a rule that minimizes the…

内生性下最优治疗规则的半参数工具变量方法AI 解读

There is a fast-growing literature on estimating optimal treatment regimes based on randomized trials or observational studies under a key identifying condition of no unmeasured confounding. Because confounding by unmeasured factors cannot generally be ruled out with certainty in observational studies or randomized trials subject to noncompliance, we propose a general instrumental variable (IV) approach to learning optimal treatment regimes under endogeneity. Specifically,…

利用工具变量进行有界、高效且多重稳健的平均处理效应估计AI 解读

Summary Instrumental variables are widely used for estimating causal effects in the presence of unmeasured confounding. Under the standard instrumental variable model, however, the average treatment effect is only partially identifiable. To address this, we propose novel assumptions that enable identification of the average treatment effect. Our identification assumptions are clearly separated from model assumptions that are needed for estimation, so researchers are not…

结构化高维模型中泛函的极小极大估计AI 解读

We introduce a new method of estimation of parameters in semiparametric and nonparametric models. The method employs $U$-statistics that are based on higher-order influence functions of the parameter of interest, which extend ordinary linear influence functions, and represent higher derivatives of this parameter. For parameters for which the representation cannot be perfect the method often leads to a bias-variance trade-off, and results in estimators that converge at a…

通过图示干预层级统一因果推断AI 解读

Identifying causal parameters from observational data is fraught with subtleties due to the issues of selection bias and confounding. In addition, more complex questions of interest, such as effects of treatment on the treated and mediated effects may not always be identified even in data where treatment assignment is known and under investigator control, or may be identified under one causal model but not another. Increasingly complex effects of interest, coupled with a…