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时变处理的边际结构均值模型：工具变量估计AI 解读

Robins introduced Marginal Structural Models (MSMs), a general class of counterfactual models for the joint effects of time-varying treatment regimes in complex longitudinal studies subject to time-varying confounding. In his work, identification of MSM parameters is established under a Sequential Randomization Assumption (SRA), which rules out unmeasured confounding of treatment assignment over time. We consider sufficient conditions for identification of the parameters of…

条件可分离效应AI 解读

Researchers are often interested in treatment effects on outcomes that are only defined conditional on posttreatment events. For example, in a study of the effect of different cancer treatments on quality of life at end of follow-up, the quality of life of individuals who die during the study is undefined. In these settings, naive contrasts of outcomes conditional on posttreatment events are not average causal effects, even in randomized experiments. Therefore, the effect in…

非单调非随机缺失数据的半参数推断：无自我删失模型AI 解读

We study the identification and estimation of statistical functionals of multivariate data missing non-monotonically and not-at-random, taking a semiparametric approach. Specifically, we assume that the missingness mechanism satisfies what has been previously called "no self-censoring" or "itemwise conditionally independent nonresponse," which roughly corresponds to the assumption that no partially-observed variable directly determines its own missingness status. We show…

Tchetgen Tchetgen 对《广义线性模型参数的弱假设推断》的讨论AI 解读

Finally, it is worth noting that in the case of identity link, Robins et al. (2008), Li et al. (2011) and Mukherjee et al. (2017) proposed minimax estimators of functional (5) of V&D, which are root-n consistent, asymptotically normal and semiparametric efficient under rate conditions for estimating nuisance functions that are significantly weaker than those of V&D in Theorem 2 (nuisance estimation rate conditions for the theorem are therefore sufficient but not necessary at…

网络因果效应的自动 g 计算AI 解读

Methods for inferring average causal effects have traditionally relied on two key assumptions: (i) the intervention received by one unit cannot causally influence the outcome of another; and (ii) units can be organized into nonoverlapping groups such that outcomes of units in separate groups are independent. In this article, we develop new statistical methods for causal inference based on a single realization of a network of connected units for which neither assumption (i)…

分类未观测混杂下双重负控调整的多重稳健因果推断AI 解读

Summary Unmeasured confounding is a threat to causal inference in observational studies. In recent years, the use of negative controls to mitigate unmeasured confounding has gained increasing recognition and popularity. Negative controls have a long-standing tradition in laboratory sciences and epidemiology to rule out non-causal explanations, although they have been used primarily for bias detection. Recently, Miao and colleagues have described sufficient conditions under…

总体间接因果效应的稳健推断：广义前门准则AI 解读

Summary Standard methods for inference about direct and indirect effects require stringent no-unmeasured-confounding assumptions which often fail to hold in practice, particularly in observational studies. The goal of the paper is to introduce a new form of indirect effect, the population intervention indirect effect, that can be non-parametrically identified in the presence of an unmeasured common cause of exposure and outcome. This new type of indirect effect captures the…

非单调随机缺失数据的逆概率加权AI 解读

The development of coherent missing data models to account for nonmonotone missing at random (MAR) data by inverse probability weighting (IPW) remains to date largely unresolved. As a consequence, IPW has essentially been restricted for use only in monotone missing data settings. We propose a class of models for nonmonotone missing data mechanisms that spans the MAR model, while allowing the underlying full data law to remain unrestricted. For parametric specifications…

尼日利亚 PEPFAR 项目中抗逆转录病毒治疗经依从性传导的路径特定效应AI 解读

Since the early 2000s, evidence has accumulated for a significant differential effect of first-line antiretroviral therapy (ART) regimens on human immunodeficiency virus (HIV) viral load suppression. This finding was replicated in our data from the Harvard President's Emergency Plan for AIDS Relief (PEPFAR) program in Nigeria. Investigators were interested in finding the source of these differences, i.e., understanding the mechanisms through which one regimen outperforms…

具有影子变量的非随机缺失下双重稳健估计量的不同形式AI 解读

Suppose we are interested in the mean of an outcome variable missing not at random. Suppose however that one has available a fully observed shadow variable, which is associated with the outcome but independent of the missingness process conditional on covariates and the possibly unobserved outcome. Such a variable may be a proxy or a mismeasured version of the outcome and is available for all individuals. We have previously established necessary and sufficient conditions for…

因果中介分析的半参数理论：效率界、多重稳健性与敏感性分析AI 解读

Whilst estimation of the marginal (total) causal effect of a point exposure on an outcome is arguably the most common objective of experimental and observational studies in the health and social sciences, in recent years, investigators have also become increasingly interested in mediation analysis. Specifically, upon evaluating the total effect of the exposure, investigators routinely wish to make inferences about the direct or indirect pathways of the effect of the exposure…