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连续暴露的增量干预效应AI 解读

Causal inference problems often involve continuous treatments, such as dose, duration, or frequency. However, identifying and estimating standard dose-response estimands requires that everyone has some chance of receiving any level of the exposure (i.e., positivity). To avoid this assumption, we consider stochastic interventions based on exponentially tilting the treatment distribution by some parameter $δ$ (an incremental effect); this increases or decreases the likelihood…

未观测混杂下预测算法的稳健设计与评估AI 解读

Abstract Predictive algorithms inform consequential decisions in settings with selective labels: outcomes are observed only for units selected by past decision makers. This creates an identification problem under unobserved confounding — when selected and unselected units differ in unobserved ways that affect outcomes. We propose a framework for robust design and evaluation of predictive algorithms that bounds how much outcomes may differ between selected and unselected…

多重异质结果下基因组数据的因果推断AI 解读

With the evolution of single-cell RNA sequencing techniques into a standard approach in genomics, it has become possible to conduct cohort-level causal inferences based on single-cell-level measurements. However, the individual gene expression levels of interest are not directly observable; instead, only repeated proxy measurements from each individual's cells are available, providing a derived outcome to estimate the underlying outcome for each of many genes. In this paper,…

时间一致中心极限定理与渐近置信序列AI 解读

Confidence intervals based on the central limit theorem (CLT) are a cornerstone of classical statistics. Despite being only asymptotically valid, they are ubiquitous because they permit statistical inference under weak assumptions and can often be applied to problems even when nonasymptotic inference is impossible. This paper introduces time-uniform analogues of such asymptotic confidence intervals, adding to the literature on confidence sequences (CS)—sequences of…

异质性因果效应估计的极小极大收敛率AI 解读

Estimation of heterogeneous causal effects - i.e., how effects of policies and treatments vary across subjects - is a fundamental task in causal inference. Many methods for estimating conditional average treatment effects (CATEs) have been proposed in recent years, but questions surrounding optimality have remained largely unanswered. In particular, a minimax theory of optimality has yet to be developed, with the minimax rate of convergence and construction of rate-optimal…

基于未测量混杂比例的敏感性分析AI 解读

In observational studies, identification of ATEs is generally achieved by assuming that the correct set of confounders has been measured and properly included in the relevant models. Because this assumption is both strong and untestable, a sensitivity analysis should be performed. Common approaches include modeling the bias directly or varying the propensity scores to probe the effects of a potential unmeasured confounder. In this article, we take a novel approach whereby…

用于识别服从者与推广因果效应的锐度工具变量AI 解读

It is well known that, without restricting treatment effect heterogeneity, instrumental variable (IV) methods only identify “local” effects among compliers, that is, those subjects who take treatment only when encouraged by the IV. Local effects are controversial since they seem to only apply to an unidentified subgroup; this has led many to denounce these effects as having little policy relevance. However, we show that such pessimism is not always warranted: it can be…

基于增量倾向得分干预的非参数因果效应AI 解读

Most work in causal inference considers deterministic interventions that set each unit’s treatment to some fixed value. However, under positivity violations these interventions can lead to nonidentification, inefficiency, and effects with little practical relevance. Further, corresponding effects in longitudinal studies are highly sensitive to the curse of dimensionality, resulting in widespread use of unrealistic parametric models. We propose a novel solution to these…

利用局部工具变量曲线进行连续工具变量的稳健因果推断AI 解读

Summary Instrumental variables are commonly used to estimate effects of a treatment afflicted by unmeasured confounding, and in practice instruments are often continuous (e.g. measures of distance, or treatment preference). However, available methods for continuous instruments have important limitations: they either require restrictive parametric assumptions for identification, or else rely on modelling both the outcome and the treatment process well (and require modelling…

治疗选择下的存活遵从者效应：及时入住重症监护室的应用AI 解读

Pretreatment selection or censoring (“selection on treatment”) can occur when two treatment levels are compared ignoring the third option of neither treatment, in “censoring by death” settings where treatment is only defined for those who survive long enough to receive it, or in general in studies where the treatment is only defined for a subset of the population. Unfortunately, the standard instrumental variable (IV) estimand is not defined in the presence of such…

连续处理效应双重稳健估计的非参数方法AI 解读

Summary Continuous treatments (e.g. doses) arise often in practice, but many available causal effect estimators are limited by either requiring parametric models for the effect curve, or by not allowing doubly robust covariate adjustment. We develop a novel kernel smoothing approach that requires only mild smoothness assumptions on the effect curve and still allows for misspecification of either the treatment density or outcome regression. We derive asymptotic properties and…