A note on the use of Laplace's approximation for nonlinear mixed-effects models
非线性混合效应模型中使用Laplace近似的一则说明
The asymptotic properties of estimates obtained using Laplace's approximation for nonlinear mixed-effects models are investigated. Unlike the restricted maximum likelihood approach, e. g. Wolfinger (1993), here the Laplace approximation is appiled only to the random effects of the integrated likelihood. This results in approximate maximum likelihood estimation. The resulting estimates are shown to be consistent with the rate of convergence depending on both the number of…