The weighted log-rank class of permutation tests: P-values and confidence intervals using saddlepoint methods
加权对数秩置换检验：用鞍点法计算 p 值与置信区间
Test statistics from the weighted log-rank class are commonly used to compare treatment with control when there is right censoring. This paper uses saddlepoint methods to determine mid-p-values from the null permutation distributions of tests from the weighted log-rank class. Analytical saddlepoint computations replace the permutation simulations and provide mid-p-values that are virtually exact for all practical purposes. The speed of these saddlepoint computations makes it…