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潜变量问题中的模糊 p 值AI 解读

We consider the problem of testing a statistical hypothesis where the scientifically meaningful test statistic is a function of latent variables. In particular, we consider detection of genetic linkage, where the latent variables are patterns of inheritance at specific genome locations. Introduced by Geyer & Meeden (2005), fuzzy p-values are random variables, described by their probability distributions, that are interpreted as p-values. For latent variable problems, we…

似然与遗传连锁：从 Fisher 到未来AI 解读

Genetic epidemiology is almost unique among the sciences in that computation of a likelihood function is the accepted approach to statistical inference. In the context of genetic linkage analysis, in which genes are mapped by analysing the dependence in inheritance of different traits, the use of likelihood dates back to the early work of Fisher and Haldane, and has seldom been seriously challenged. After introducing the underlying genetic concepts, this paper reviews the…