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细胞类型反卷积的统计推断AI 解读

Abstract Integrating heterogeneous datasets across different measurement platforms poses fundamental challenges for statistical inference. An important example is cell type deconvolution, where cell type proportions in bulk RNA-seq data are estimated using reference single-cell data from different sources, leading to platform-specific scaling effects, measurement noise, and biological heterogeneity. Existing methods often treat estimated proportions as observed in downstream…

关于“非参数经验贝叶斯分析的置信区间”的讨论AI 解读

We congratulate Ignatiadis and Wager (IW) on this significant step forward, incorporating uncertainty in the estimated prior into empirical Bayes (EB) analysis. EB analyses have traditionally ignor...