A Two-Way Semilinear Model for Normalization and Analysis of cDNA Microarray Data
用于 cDNA 微阵列归一化与分析的双向半线性模型
A basic question in analyzing cDNA microarray data is normalization, the purpose of which is to remove systematic bias in the observed expression values by establishing a normalization curve across the whole dynamic range. A proper normalization procedure ensures that the normalized intensity ratios provide meaningful measures of relative expression levels. We propose a two-way semilinear model (TW–SLM) for normalization and analysis of microarray data. This method does not…