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The synthetic instrument: from sparse association to sparse causation

合成工具变量:从稀疏关联到稀疏因果效应

Abstract In many observational studies, researchers are often interested in the effects of multiple exposures on a single outcome. Standard approaches for high-dimensional data, such as the Lasso, assume that the associations between the exposures and the outcome are sparse. However, these methods do not estimate causal effects in the presence of unmeasured confounding. In this paper, we consider an alternative approach that assumes the causal effects under consideration are…

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Convergence and optimality of the EM algorithm under multi-component Gaussian mixture models

多成分高斯混合模型下 EM 算法的收敛与最优性

Summary Gaussian mixture models are fundamental statistical tools for modelling heterogeneous data. Due to the nonconcavity of the likelihood function, the expectation-maximization (EM) algorithm is widely used for parameter estimation of each Gaussian component. Existing analyses of the EM algorithm’s convergence to the true parameter focus on either the two-component case or multi-component settings with known mixing probabilities and isotropic covariance matrices. In this…

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Successive Classification Learning for Estimating Quantile Optimal Treatment Regimes

估计分位数最优处理规则的序贯分类学习

Quantile optimal treatment regimes (OTRs) aim to assign treatments that maximize a specified quantile of patients’ outcomes. Compared to treatment regimes that target the mean outcomes, quantile OTRs offer fairer regimes when a lower quantile is selected, as it improves outcomes for vulnerable patients. In this paper, we propose a novel method for estimating quantile OTRs by reformulating the problem as a successive classification task, solvable via training a sequence of…

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Stationarity of Manifold Time Series

流形时间序列的平稳性

In modern interdisciplinary research, manifold time series data have been garnering more attention. A critical question in analyzing such data is “stationarity”, which reflects the underlying dynamic behavior and is crucial across various fields like cell biology, neuroscience and empirical finance. Yet, there has been an absence of a formal definition of stationarity that is tailored to manifold time series. This work bridges this gap by proposing the first definitions of…

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The Impact of Job Stability on Monetary Poverty in Italy: Causal Small Area Estimation

工作稳定性对意大利货币贫困的影响:因果小区域估计

Job stability – encompassing secure contracts, adequate wages, social benefits, and career opportunities – is a critical determinant in reducing monetary poverty, as it provides households with reliable income and enhances economic well-being. This study draws on EU-SILC survey and census data to estimate the causal effect of job stability on monetary poverty across Italian provinces, quantifying its influence, and analyzing regional disparities. We introduce a novel causal…

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Functional principal component analysis with informative observation times

信息性观测时点下的函数主成分分析

Summary Functional principal component analysis has been shown to be invaluable for revealing variation modes of longitudinal outcomes, which serve as important building blocks for forecasting and model building. Decades of research have advanced methods for functional principal component analysis, often assuming independence between the observation times and longitudinal outcomes. Yet such assumptions are fragile in real-world settings where observation times may be driven…

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Promises of parallel outcomes

平行结局的潜力

Summary A key challenge in causal inference from observational studies is the identification and estimation of causal effects in the presence of unmeasured confounding. In this paper, we introduce a novel approach for causal inference that leverages information in multiple outcomes to deal with unmeasured confounding. An important assumption in our approach is conditional independence among multiple outcomes. In contrast to existing proposals in the literature, the roles of…

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Covariance Estimation for Matrix-valued Data

矩阵值数据的协方差估计

Covariance estimation for matrix-valued data has received an increasing interest in applications. Unlike previous works that rely heavily on matrix normal distribution assumption and the requirement of fixed matrix size, we propose a class of distribution-free regularized covariance estimation methods for high-dimensional matrix data under a separability condition and a bandable covariance structure. Under these conditions, the original covariance matrix is decomposed into a…

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Causal inference on distribution functions

以分布函数为结果的因果推断

Abstract Understanding causal relationships is one of the most important goals of modern science. So far, the causal inference literature has focused almost exclusively on outcomes coming from the Euclidean space Rp. However, it is increasingly common that complex datasets are best summarized as data points in nonlinear spaces. In this paper, we present a novel framework of causal effects for outcomes from the Wasserstein space of cumulative distribution functions, which in…

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Identifiability of causal effects with multiple causes and a binary outcome

多重处理与二元结果下因果效应的可识别性

Summary Unobserved confounding presents a major threat to causal inference in observational studies. Recently, several authors have suggested that this problem could be overcome in a shared confounding setting where multiple treatments are independent given a common latent confounder. It has been shown that under a linear Gaussian model for the treatments, the causal effect is not identifiable without parametric assumptions on the outcome model. In this note, we show that…

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L2RM: Low-Rank Linear Regression Models for High-Dimensional Matrix Responses

L2RM:高维矩阵响应的低秩线性回归模型

The aim of this paper is to develop a low-rank linear regression model (L2RM) to correlate a high-dimensional response matrix with a high dimensional vector of covariates when coefficient matrices have low-rank structures. We propose a fast and efficient screening procedure based on the spectral norm of each coefficient matrix in order to deal with the case when the number of covariates is extremely large. We develop an efficient estimation procedure based on the trace norm…

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Partially functional linear regression in high dimensions

高维部分函数型线性回归

In modern experiments, functional and nonfunctional data are often encountered simultaneously when observations are sampled from random processes and high-dimensional scalar covariates. It is difficult to apply existing methods for model selection and estimation. We propose a new class of partially functional linear models to characterize the regression between a scalar response and covariates of both functional and scalar types. The new approach provides a unified and…

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