论文检索

中介变量与结果非随机缺失时的中介分析AI 解读

Mediation analysis is widely used for investigating direct and indirect causal pathways through which an effect arises. However, many mediation analysis studies are challenged by missingness in the mediator and outcome. In general, when the mediator and outcome are missing not at random, the direct and indirect effects are not identifiable without further assumptions. We study the identifiability of the direct and indirect effects under some interpretable mechanisms that…

最大秩可重复性：评估重复实验可重复性的非参数方法AI 解读

The identification of reproducible signals from the results of replicate high-throughput experiments is an important part of modern biological research. Often little is known about the dependence structure and the marginal distribution of the data, motivating the development of a nonparametric approach to assess reproducibility. The procedure, which we call the maximum rank reproducibility (MaRR) procedure, uses a maximum rank statistic to parse reproducible signals from…

利用充分降维估计基于回归的因果效应AI 解读

In many causal inference problems the parameter of interest is the regression causal effect, defined as the conditional mean difference in the potential outcomes given covariates. In this paper we discuss how sufficient dimension reduction can be used to aid causal inference, and we propose a new estimator of the regression causal effect inspired by minimum average variance estimation. The estimator requires a weaker common support condition than propensity score-based…

利用基因表达数据进行肿瘤的贝叶斯分类AI 解读

Summary Precise classification of tumours is critical for the diagnosis and treatment of cancer. Diagnostic pathology has traditionally relied on macroscopic and microscopic histology and tumour morphology as the basis for the classification of tumours. Current classification frameworks, however, cannot discriminate between tumours with similar histopathologic features, which vary in clinical course and in response to treatment. In recent years, there has been a move towards…