Likelihood-Based Inference on Haplotype Effects in Genetic Association Studies
遗传关联研究中单倍型效应的似然推断
A haplotype is a specific sequence of nucleotides on a single chromosome. The population associations between haplotypes and disease phenotypes provide critical information about the genetic basis of complex human diseases. Standard genotyping techniques cannot distinguish the two homologous chromosomes of an individual, so only the unphased genotype (i.e., the combination of the two homologous haplotypes) is directly observable. Statistical inference about…