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Maximum likelihood estimation for semiparametric regression models with interval-censored multistate data

区间删失多状态数据半参数回归模型的最大似然估计

Summary Interval-censored multistate data arise in many studies of chronic diseases, where the health status of a subject can be characterized by a finite number of disease states and the transition between any two states is only known to occur over a broad time interval. We relate potentially time-dependent covariates to multistate processes through semiparametric proportional intensity models with random effects. We study nonparametric maximum likelihood estimation under…

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Marginal proportional hazards models for multivariate interval-censored data

多元区间删失数据的边际比例风险模型

Summary Multivariate interval-censored data arise when there are multiple types of events or clusters of study subjects, such that the event times are potentially correlated and when each event is only known to occur over a particular time interval. We formulate the effects of potentially time-varying covariates on the multivariate event times through marginal proportional hazards models while leaving the dependence structures of the related event times unspecified. We…

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Maximum likelihood estimation for semiparametric regression models with panel count data

面板计数数据半参数回归模型的最大似然估计

Summary Panel count data, in which the observation for each study subject consists of the number of recurrent events between successive examinations, are commonly encountered in industrial reliability testing, medical research and other scientific investigations. We formulate the effects of potentially time-dependent covariates on one or more types of recurrent events through nonhomogeneous Poisson processes with random effects. We employ nonparametric maximum likelihood…

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Semiparametric Transformation Models for Point Processes

点过程的半参数变换模型

In this article, we propose a family of semiparametric transformation models for point processes with positive jumps of arbitrary sizes. These models offer great flexibilities in formulating the effects of covariates on the mean function of the point process while leaving the stochastic structure completely unspecified. We develop a class of estimating equations for the baseline mean function and the vector-valued regression parameter based on censored point processes and…

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